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  • Periactin for Migraines: Fact or Fiction?

    Understanding Migraines: Symptoms and Common Treatments


    Migraines are more than just headaches; they are complex neurological events that manifest through intense, throbbing pain, often accompanied by nausea, visual disturbances, and sensitivity to light and sound. Approximately 12% of the population suffers from migraines, making them a common ailment that disrupts daily life. While the exact cause remains elusive, genetic and environmental factors are known contributors. Standard treatments aim to either prevent attacks or alleviate symptoms once they occur.

    Common treatments are categorized into acute and preventive options:

    Treatment Type Examples
    Acute Triptans, NSAIDs
    Preventive Beta-blockers, Antidepressants

    Effective management often requires a tailored approach, balancing medication with lifestyle modifications like stress management and dietary changes.



    Periactin: a Surprising Player in Migraine Relief



    In the realm of migraine relief, Periactin emerges as an unexpected contender. Originally an antihistamine used for allergy symptoms, Periactin—scientifically known as cyproheptadine—has gained attention for its potential in easing the neurological storm of migraines. While its primary function is to counteract allergic reactions, Periactin's mode of action, involving serotonin antagonism and calcium channel blocking, intriguingly intersects with migraine pathophysiology.

    The link between serotonin and migraines is well-documented, as fluctuations in serotonin levels are thought to trigger the onset of migraine attacks. By modulating these levels, Periactin may offer relief by preventing the serotonin surge that leads to these debilitating headaches. Furthermore, its ability to impede calcium channels might mitigate the overactive neuronal activity common in migraines, providing a unique therapeutic angle.

    The surprising aspect of Periactin's role in migraine relief is its dual action as a sedative and appetite stimulant, qualities that diverge from traditional migraine interventions. This dual effect can be therapeutic, offering sedation during an acute migraine episode while paradoxically raising concerns about its suitability for all patients. These side effects require careful consideration and monitoring, particularly regarding weight gain and drowsiness.

    As the journey from allergic relief to migraine management unfolds, Periactin's potential to become a fixture in migraine therapeutics continues to intrigue clinicians and researchers alike. Its role in treatment paradigms remains under continuous evaluation, paving the way for new discussions on medication repurposing.



    How Periactin Is Believed to Help Migraines


    Periactin, an antihistamine known generically as cyproheptadine, has shown promise in alleviating migraines by blocking serotonin, a neurotransmitter implicated in headache pathways. This medication's ability to inhibit serotonin receptors suggests it could temper the vascular spasms often associated with migraine episodes, helping to ease the intensity or frequency of attacks.

    Moreover, Periactin's sedative properties might contribute to its effectiveness by promoting relaxation, which can further aid in reducing migraine triggers. Its multifaceted action provides an intriguing alternative for those seeking relief from frequent headaches.



    Scientific Studies: Periactin's Efficacy and Safety



    Research into Periactin, also known as cyproheptadine, sheds light on its potential as a migraine treatment. Although originally developed as an antihistamine, Periactin's ancillary effects have ignited interest in the scientific community. Preliminary studies suggest that its action as a serotonin antagonist might play a key role in alleviating migraine symptoms. By interfering with serotonin, a neurotransmitter involved in migraine pathophysiology, Periactin may reduce the frequency and intensity of attacks.

    Despite promising initial findings, the scientific inquiry into Periactin's efficacy remains limited, with a need for more expansive and rigorous clinical trials. Some trials hinted at its potential to mitigate migraines, but safety assessments revealed side effects such as drowsiness and weight gain, which temper enthusiasm.

    In comparison to newer migraine treatments, Periactin's side effect profile requires cautious consideration. However, for patients unresponsive to conventional therapies, Periactin may offer an alternative, sparking a need for comprehensive studies to conclusively determine its place in migraine management.



    Comparing Periactin to Other Migraine Medications


    When exploring migraine relief options, one might find Periactin sitting unassumingly beside well-known medications like triptans and beta-blockers. Unlike conventional treatments that often focus on vascular constriction or neurotransmitter modulation, Periactin offers a unique approach, believed to balance serotonin levels and reduce inflammation. Yet, how does it fare against more established medications?

    Medication Mechanism Common Side Effects
    Periactin Antihistamine, serotonin antagonist Drowsiness, increased appetite
    Triptans Selective serotonin receptor agonists Nausea, dizziness
    Beta-blockers Blocks adrenaline effects, reducing blood pressure Fatigue, depression

    Patient experiences underscore the individual response to these treatments, making it crucial for patients and doctors to navigate through a personalized path to relief.



    Patient Experiences: Success Stories and Challenges


    From firsthand accounts, many migraine sufferers have found relief with Periactin. One patient, Elizabeth, shares how her debilitating headaches improved significantly within weeks, highlighting a drastic reduction in both frequency and intensity. Despite these success stories, not all experiences are straightforward. Some patients face challenges like drowsiness and weight gain, common Periactin side effects, making it unsuitable for everyone. As with any treatment, the effectiveness of Periactin varies, illustrating the importance of individualized approaches in the complex journey of migraine management.





ARIZONA PSYCHIATRIC SOCIETY 2024-2025 EXECUTIVE Board

President: Nicholas Ahrendt, MD President-Elect: Margaret Balfour, MD, PhDVice President: Brenner Freeman, MDTreasurer: Robert Rymowicz, DOSecretary: Chiranjir "Ravi" Narine, MD Co Resident-Fellow Member Representatives: Nehal Samra, MD Creighton Matthew Mitchell, MD UA-PhoenixGagan Singh, MD UA-Tucson
APA Assembly Representatives: Jason Curry, DO (serves term concluding 2024) Jasleen Chhatwal, MBBS, MD (two-year term concluding 2024)Payam Sadr, MD (one-year term concluding 2024) Past President Gagandeep Singh, MD, DFAPA Stephen "Larry" Mecham, DO The Society thanks these members for their leadership.

Celebrating our members

Chase was born and raised in Phoenix, AZ, and attended ASU for a bachelor’s degree in business then attended KCUMB for medical school in Kansas City. He was excited to return home to AZ when he found out he'd been matched with UACOM – Phoenix for his psychiatry residency.
He was first drawn to the field of psychiatry during his years in medical school as he found the psychiatric subject matter and the patients to be the most engaging and interesting of all his studies. He quickly came to realize that without a healthy mind, one is unable to thoroughly experience life constructive way. He wanted to be the person to help those struggling with mental illness as he found these cases and experiences to be the most rewarding in medicine.
Dr. Crookham said he has been lucky enough to have been matched at a great psychiatric residency program where he gets to learn from great mentors and colleagues every day. He believes his passion for psychiatry along with the relationships he's developed with his colleagues and mentors will carry him to be a lifelong learner and devoted psychiatrist for his future patients.
Meghan is a graduate of Lincoln Memorial University, DeBusk College of Osteopathic Medicine.
She received her Bachelor of Arts from the University of Denver in French and Biology with a concentration in Cognitive Neuroscience.
She is currently a chief resident at UACOM-Tucson in her final year of psychiatry training and will be starting a fellowship in Addiction Medicine at the University of Arizona, Tucson in July.
Her professional interests include physician mental health, adult consult liaison and addiction psychiatry.
In her personal time, she enjoys home design projects, spending time with family, learning about plants, and exploring new places.
Dr. Hintze is currently honeymooning in Japan! Congratulations!!
Danny is originally from Phoenix. Graduated from Brophy, ASU, and UA Tucson Medical School. His background is in economics, philosophy of science, and rational decision-making.
He was drawn to psychiatry because of the conceptual complexity and the profound impact even relatively simple pharmaceutical, medical, and psychotherapeutic interventions can have to empower patients and their families.
As a mentor, he wanted to recognize the many people within the Arizona Medical Community, particularly at UA Tucson, Valleywise, and within organized medicine who have worked to protect and promote medicine as a joyful, compassionate, and healing experience for patients and for all of us who help care for them.

ARIZONA PSYCHIATRIC SOCIETY past presidents

Otto L. Bendheim, M.D. 1960-1961Warren S. Williams, M.D. 1961-1963T. Richard Gregory, M.D. 1963-1964Boris Zemsky, M.D. 1964-1965 Hal J. Breen, M.D. 1965-1966Joseph M. Green, M.D. 1966-1967Irene M. Josselyn, M.D. 1967-1968Hubert R. Estes, M.D. 1968-1969Richard H. Bruner, M.D. 1969-1970Thomas F. Kruchek, M.D. 1970-1971David S. Burgoyne Sr., M.D. 1971-1972Marshall W. Jones, M.D. 1972-1973Harold D. Haeussler, M.D. 1973-1974William B. Haeussler, M.D. 1974-1975Edward S. Gelardin, M.D. 1975-1976Hugo L. Cozzi, M.D. 1976-1977Robert F. Meyer, M.D. 1977-1978James E. Campbell, M.D. 1978-1979Stuart M. Gould, M.D. 1979-1980Elliot M. Heiman, M.D. 1980-1981Stephen V. Shanfield, M.D. 1981-1982Jerry A. Biggs, M.D. 1982-1983Robert C. Shapiro, M.D. 1983-1984Dennis C. Westin, M.D. 1984-1985John H. Jarvis, M.D. 1985-1986James G. Hill, M.D. 1986-1987Robert P. Bevan, M.D. 1987-1988Eugene J. Kinder, M.D. 1988-1989 James M. Campbell, M.D. 1989-1990David S. Burgoyne II, M.D. 1990-1991
Stuart W. Hollingsworth, M.D. 1991-1992Kevin J. Leehey, M.D. 1992-1993Stephen S. Brockway, M.D. 1993-1994Michael H. Stumpf, M.D. 1994-1995Lauro Amezcua-Patino, M.D. 1995-1996David S. Burgoyne II, M.D. 1997-1998Glenn Lippman, M.D. 1998-1999Lisa Jones, M.D. 1999-2000David J. Coons, M.D. 2000-2001James M. Campbell, M.D. 2001-2002Bradley Johnson, M.D. 2002-2003David W. Leicken, M.D. 2003-2004Thomas N. Crumbley, M.D. 2004-2006Jeffrey L. Schwimmer, M.D., M.P.H. 2006-2007Stephen O. Morris, M.D. 2007-2008Jack L. Potts, M.D. 2008-2009Elizabeth A. Kohlhepp, M.D. 2009-2010Michael E. Brennan, M.D. 2010-2011Gretchen Alexander, M.D. 2011-2012Tariq M. Ghafoor, M.D. 2012-2013Joanna K. Kowalik, M.D., M.P.H., 2013-2014Payam M. Sadr, M.D., 2014-2015Roland Segal, M.D., 2015-2016Gurjot Marwah, M.D., 2016-2017Aaron Wilson, M.D., 2017-2018Mona Amini, M.D., 2018-2019 Don J. Fowls, M.D., 2019-2020 Jasleen Chhatwal, M.B.B.S., M.D., 2020-2022 Stephen Larry Mecham, DO, 2022-2023 Gagandeep Singh, MD, DFAPA 2023-2024
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